Mark Duplass Opens Up About Decades of Anxiety and Depression

Mark Duplass, the actor, writer, and producer known for his work in The Morning Show, The League, and Togetherness, spoke publicly in mid-June 2025 about his long-term battle with anxiety and depression. In a candid interview and social media post, Duplass shared that he has lived with these conditions for decades and continues to manage them through therapy, medication, and lifestyle adjustments.

At 48, Duplass said he felt it was time to speak openly to help others feel less alone. “I’ve been living with anxiety and depression for most of my adult life,” he wrote. “It comes and goes in waves. But I’ve found ways to stay afloat, and I want people to know they can too.”

He explained that his symptoms began in his twenties and worsened during periods of stress and overwork. Despite achieving success in Hollywood as a writer, actor, and director, Duplass said he often felt overwhelmed, emotionally drained, and unable to enjoy his accomplishments.

“I would be smiling on set and panicking inside,” he said in the interview. “People thought I had it all together, but I was often falling apart.”

Duplass credited therapy as one of the most important tools in managing his mental health. He also said that regular exercise, improved sleep habits, and selective use of antidepressants have helped him regain stability and clarity. “It’s not a quick fix. It’s a process. But it works,” he emphasized.

He also spoke about the specific pressure men often feel to remain silent about emotional pain. Duplass said societal expectations kept him quiet for too long. He now wants to help change that by speaking out and encouraging others to do the same.

“There’s a stigma, especially for men, around talking about mental health,” he said. “But silence makes it worse. The more we talk, the more we heal.”

Duplass’s message quickly gained traction online. Supporters praised his honesty and openness, with many sharing their own mental health stories in response. Fellow actors, including his brother Jay Duplass and colleagues from the indie film community, applauded him for starting an important conversation.

In recent years, Duplass has worked on projects that explore emotional and psychological themes, often blending humor and vulnerability. He said these stories reflect his personal struggles and have helped him connect with audiences who are facing similar challenges.

Beyond his acting and producing work, Duplass has plans to partner with mental health organizations to promote awareness and education. He hopes to create digital content and public campaigns that target stigma, especially among men in creative industries.

By choosing to share his journey, Duplass is encouraging others to seek help without shame. His message is simple and direct: anxiety and depression are real, but support and treatment make a difference.

Mark Duplass continues to live and work with purpose, using his platform to remind people that strength includes being honest, asking for help, and caring for your mental well-being.